PROSES PEMBUATAN DAN PENGEMASAN TABLET SEDIAAN SOLID : LITERATURE REVIEW
Keywords:
Eksipien tablet, Kempa langsung, Pengemasan farmasi, Quality by Design, Sediaan solidAbstract
Tablet merupakan sediaan solid farmasi yang paling banyak diproduksi dan dikonsumsi secara global, namun proses pembuatan dan pengemasannya melibatkan rangkaian tahapan teknis yang kompleks dan saling berpengaruh terhadap mutu akhir produk. Kajian ini bertujuan menelaah secara komprehensif perkembangan teknologi pembuatan tablet mencakup rekayasa eksipien, metode granulasi, validasi proses, evaluasi mutu fisik, serta inovasi sistem pengemasan sediaan solid farmasi. Penelitian ini menggunakan pendekatan literature review dengan menelusuri tiga puluh artikel ilmiah dari pangkalan data Google Scholar, PubMed, dan Science Direct, yang dipublikasikan antara tahun 2014 hingga 2024. Hasil kajian menunjukkan bahwa teknik ko-proses dan spray drying efektif meningkatkan sifat fungsional eksipien untuk kempa langsung, pendekatan Quality by Design (QbD) menghasilkan proses granulasi yang lebih robust dan konsisten, serta inovasi pengemasan berbasis material barrier tinggi dan kemasan cerdas berkontribusi nyata terhadap stabilitas dan keamanan produk. Disimpulkan bahwa integrasi antara rekayasa eksipien, optimasi proses berbasis QbD, dan sistem pengemasan yang tepat merupakan strategi holistik yang esensial dalam menjamin mutu, efektivitas, dan keamanan sediaan tablet secara menyeluruh.
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Copyright (c) 2026 Nur’idayu, Riyan Hidayat Meliala, Dea Kristiani, Aisyah Arianti, Marisa Zahrani Nasution, Dhea Meiza Azzahra, Mohammad Fauzil Adhim, Naifa Adelia Nurahmi, Dela Amelia, Reyny Puspita Lubis
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